ChemicalBook > CAS DataBase List > 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- Product Name
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- CAS No.
- 120964-45-6
- Chemical Name
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- Synonyms
- DZNepHCl;NSC 617989 HCl;DZNEP; NSC 617989;DZNep hydrochloride;3-deazaneplanocin A HCl;NSC 617989 hydrochloride;3-deazaneplanocin A (DZNeP) HCl;3-Deazaneplanocin hydrochloride;DZNeP (3-deazaneplanocin A) HCl;3-Deazaneplanocin A (hydrochloride)
- CBNumber
- CB12623932
- Molecular Formula
- C12H15ClN4O3
- Formula Weight
- 298.7255
- MOL File
- 120964-45-6.mol
More
Less
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Property
- Melting point:
- 168-169℃
- storage temp.
- -20°C
- solubility
- H2O: ≥5mg/mL
- form
- Tan solid
- color
- white to beige
- Water Solubility
- Soluble in water (10mM)
- InChIKey
- UNSKMHKAFPRFTI-FDKLLANESA-N
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0305
- Product name
- 3-Deazaneplanocin A hydrochloride
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $473
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 252790
- Product name
- Histone Methyltransferase EZH2 Inhibitor, DZNep
- Packaging
- 2mg
- Price
- $303
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11102
- Product name
- 3-Deazaneplanocin A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $92
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11102
- Product name
- 3-Deazaneplanocin A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $174
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0305
- Product name
- 3-Deazaneplanocin A hydrochloride
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $1590
- Updated
- 2024/03/01
More
Less
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Chemical Properties,Usage,Production
Uses
3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities.
Uses
3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.
General Description
3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.
Biochem/physiol Actions
3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.
target
histone methyltransferase
storage
-20°C
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Suppliers
More
Less
View Lastest Price from 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Deazaneplanocin A hydrochloride 120964-45-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Deazaneplanocin A hydrochloride 120964-45-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
Career Henan Chemical Co
- Product
- 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- 120964-45-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23